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Normalization of 24-hour intraesophageal acid exposure was correlated to gastric pH>4 for at least 35% of the 24-hour period; this level was achieved in 90% of subjects receiving Aciphex 20 mg and in 100% of subjects receiving Aciphex 40 mg. The safety and effectiveness of Aciphex for other pediatric indications have not been established. The mean decreases from baseline in average daytime and nighttime heartburn scores were significantly greater for Aciphex 20 mg as compared to placebo at week 4. The name and strength, in mg, (Aciphex 20) is imprinted on one side. Aciphex was significantly superior to placebo in producing healing of duodenal ulcers.

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