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Brand name: metformin
Generic name: glucophage, Metformin, Glucophage, Diabex, Diaformin, Fortamet, Riomet, Glumetza, metfornin, metforrnin
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Should secondary failure occur with combined Amaryl/metformin therapy, it may be necessary to initiate insulin therapy. Use of metformin and rosiglitazone can increase the risk of serious side effects in these patients. In patients where monotherapy with Amaryl or metformin has not produced adequate glycemic control, the combination of Amaryl and metformin may have a synergistic effect, since both agents act to improve glucose tolerance by different primary mechanisms of action. Combined use of glimepiride with insulin or metformin may increase the potential for hypoglycemia. Amaryl may be used concomitantly with metformin when diet, exercise, and Amaryl or metformin alone do not result in adequate glycemic control. Furthermore, discontinuation or dose reduction of rosiglitazone maleate/metformin hydrochloride must be considered.
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